High-Yield Pharmacology: Differentiating Loop vs Potassium-Sparing Diuretics

Diuretics promote urine flow by inhibiting sodium reabsorption along the renal tubules.

Diuretic Classes

• Loop Diuretics (e.g., Furosemide): Inhibits Na/K/2Cl cotransporter in ascending loop of Henle. Can cause hypokalemia, ototoxicity, and dehydration.
• Potassium-Sparing Diuretics (e.g., Spironolactone): Antagonizes aldosterone in distal tubule. Can cause hyperkalemia.